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KMID : 1140120070120040287
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Cancer Prevention Research
2007 Volume.12 No. 4 p.287 ~ p.295
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The Leaf Part of Capsicum annuum L. var. angulosum Mill Reduces the Hepatic Detoxification Capacity
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Lee Won-Sup
Kwak Soo-Young
Lee Un-Joo
Chung Yong-Za
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Abstract
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We previously demonstrated that the leaf part of Capsicum annuum L. var. angulosum Mill (leaf of green peppers, CA-L) has anti-tumor activity on the cancer cells. In this study, we evaluated the changes in hepatic enzymes especially relating to the detoxification for the evaluation of its effects on the liver, because it is recently reported that deficiency of hepatic enzymes relating to the detoxification can be a predisposing factor for the drug-induced hepatitis, and the other adverse clinical effects on rats and mice. We found that daily administration of the extract of CA-L (ECA-L) to the rats and mice for 2 weeks lead to decreases in glutathione and glutathione S-transferase levels of the liver in dose-dependent manners in rats and mice (p=0.029, p=0.022, respectively). In addition, the γ-GTP levels in the liver were increased 2 weeks after administration of ECA-L in rats and mice in dose-dependent manners. No other adverse clinical effects on rats and mice were found except on the liver. Our study suggests that 2-weeks administration of ECA-L to the rats and mice should decreases in hepatic detoxification capacity in dose-dependent manners. In this report, it can be assumed that more than 2 weeks administration of ECA-L should be a risk factor for drug-induced hepatitis, especially in combination with potential hepatotoxic drugs. (Cancer Prev Res 12, 287-295, 2007)
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KEYWORD
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Capsicum annuum L. var. angulosum Mill, Detoxification, Glutathione, Glutathione Stransferase, Hepatotoxicity, Leaf
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